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No-carrier-added Lutetium (177Lu) chloride
EndolucinBeta® is an innovative radiopharmaceutical precursor for targeted radionuclide therapies and contains the active substance 177Lu chloride as a no-carrier-added radioisotope. The use of no-carrier-added (n.c . a.) 177Lu is excellent for the efficacy and quality of therapeutic radiopharmaceuticals. The production route of EndolucinBeta® takes advantage of highly enriched Ytterbium-176 as starting material, thereby providing the highest specific activity and an unprecedented level of radionuclidic purity.
Using 177Lu in its pure form enables the specific radioactivity to be greatly increased by up to 6-times. As a result, the superior performance creates favorable preconditions for efficient radiolabeling of biomolecules such as peptides and antibodies.
NO-CARRIER-ADDED VS. CARRIER-ADDED 177Lu
· EndolucinBeta® displays superiorcharacteristics when compared to the carrier-added radioisotope.
· The specific activity of n. c. a. 177Lu is upto 6 times higher than of the c. a. isotope.
· Due to its slower decrease of specific activityEndolucinBeta® offers favorable preconditions for an efficient radiolabelingreaction over its entire shelf-life of 9 days after production.
· Furthermore, EndolucinBeta® provides thehighest achievable radionuclidic purity. In comparison to the c.a. isotopeEndolucinBeta® contains no metastable 177mLu and does not require any costlylogistics and storage of contaminated radioactive waste.
Key Advantages
· EndolucinBeta® displays superiorcharacteristics when compared to the carrier-added radioisotope.
· The specific activity of n. c. a. 177Lu is upto 6 times higher than of the c. a. isotope.
· Due to its slower decrease of specific activityEndolucinBeta® offers favorable preconditions for an efficient radiolabelingreaction over its entire shelf-life of 9 days after production.
· Furthermore, EndolucinBeta® provides thehighest achievable radionuclidic purity. In comparison to the c.a. isotopeEndolucinBeta® contains no metastable 177mLu and does not require any costlylogistics and storage of contaminated radioactive waste.
