With ITG’s Lu-177 n.c.a., because of its outstanding specific activity and high purity, the amount of peptide or antibodies used for labeling can be reduced by 50% or more. Additionally a high radiolabeling yield can be achieved even 11 days after post-calibration time (of course there is decay based on the half-life of 6.65 days). In the Lu-177 n.c.a. 4 out of 5 Lutetium atoms are radioactive. In the Lu-177 c.a. it is the opposite: Only 1 out of 5 atoms is radioactive. This is the reason for the much higher specific activity of our Lu-177 n.c.a.
The Lu-177 that can be bought from other suppliers is always carrier added Lu-177 (c.a.) with poor specific activity and poor radionuclide (radioisomeric) purity. It can’t be avoided due to production route. A minimum of 0.1% of the activity of the Lu-177 c.a. is the long-lived (160 days half-life) Lu-177m isomer. It is going into the patients together with the wanted short lived Lu-177 isomer. This isomer can’t be found in our Lu-177 n.c.a.
Besides injecting long lived nuclide into patients, also waste disposal problems are caused by this long lived isomer. The waste problem of which very few customers were or are aware has made a lot of European hospitals convert to our Lu-177 n.c.a. as hospitals risk that all of their decay tanks get blocked with the long-lived Lu-177m isomer which you only find in carrier added Lu-177. To give you two recent examples: One customer had to close down his radioiodine therapy unit for three weeks because of blockage of his decay tanks with Lu-177m. Another customer had to empty his decay tanks for an amount in excess of 100,000 EUR to get rid of his waste because of Lu-177m. It is the same with all solid material used for the handling: it stays contaminated for years. Not so with our Lu-177 n.c.a.!
Because of our worldwide network of irradiating reactors (>10) we can deliver Lu-177 n.c.a. every weekday from Monday thru Friday in 52 weeks per year. We ship our Lu-177 n.c.a. world-wide.
NO-CARRIER-ADDED VS. CARRIER-ADDED 177Lu :
- Showing superior characteristics when compared to the carrier-added radioisotope
- The specific activity of n. c. a. 177Lu is up to 6 times higher than of the c. a. isotope.
- Due to its slower decrease of specific activity EndolucinBeta® offers favorable preconditions for an efficient
radiolabeling reaction over its entire shelf-life of 9 days after production.
- No-carrier added 177Lu provides the highest achievable radionuclidic purity. ITG’s 177Lu, In comparison to the c.a. isotope, contains no metastable 177mLu and does not require any costly logistics and storage of contaminated radioactive waste.